One of the most famous slave uprisings in Black history was the Nat Turner Rebellion, also known as Nat Turner's Rebellion or the Southampton Insurrection. Nat Turner was an enslaved African American who led a rebellion of slaves in Southampton County, Virginia, in August 1831. The rebellion resulted in the deaths of around 60 white people, and Turner and his followers were eventually captured and executed.

The Nat Turner Rebellion was one of the most significant slave uprisings in American history, primarily due to its violent nature and the fear it instilled in white slaveholders. The rebellion sparked harsher legislation restricting the rights and movements of enslaved people, and it also led to increased surveillance and control of Black communities.

Despite the violent and tragic outcome of the rebellion, Nat Turner's actions have been viewed by many as a courageous and powerful act of resistance against the institution of slavery. Turner's story has been remembered and honored in Black history as an example of the courage and resilience of enslaved people who fought against the oppressive system of slavery.