There have been several notable slave uprisings in Black history, where enslaved people revolted against their oppressors in an effort to gain their freedom. One of the most famous uprisings in American history is Nat Turner's Rebellion, which took place in 1831 in Virginia. Nat Turner, a slave who believed he was chosen by God to lead a rebellion, organized a group of fellow slaves and launched a violent uprising that resulted in the deaths of approximately 60 white people. The rebellion was eventually suppressed, and Turner was captured and executed.

Another significant slave uprising was the Haitian Revolution, which took place in the French colony of Saint-Domingue (now Haiti) from 1791 to 1804. Enslaved Africans, led by figures such as Toussaint Louverture and Jean-Jacques Dessalines, rose up against their French colonizers and successfully fought for independence, making Haiti the first independent Black republic in the world.

Other notable slave uprisings include the Stono Rebellion in South Carolina in 1739, the Gabriel Prosser Plot in Virginia in 1800, and the Denmark Vesey Plot in South Carolina in 1822. These uprisings, though often unsuccessful in achieving their immediate goals, served as acts of resistance against the institution of slavery and inspired future generations of freedom fighters in the struggle for liberation and equality.